The Children’s Oral Health and Nutrition Project in Vietnam aims to contribute solutions to two global health epidemics– childhood tooth decay and malnutrition. The project’s intervention is a set of cost-effective preventive measures. It includes free dental supplies (toothbrushes, toothpaste, floss) for all study children and family members, application of fluoride varnish to children’s teeth biannually, referral of children with tooth decay to local dentists, and education about oral health and nutrition for community health workers, teachers, and families. The goal is to demonstrate that the project is a cost-effective and valid preventive health initiative that addresses the neglected global diseases of childhood tooth decay and malnutrition. Ultimately, the goal is to make the project sustainable and ensure its expansion with the support of the Vietnamese government to reach more children across all regions in Vietnam.